AC-3933, a novel cognitive enhancer : I. Neuropharmacological properties.

A Novel Dynamic Voltage Regulator with a Multi-level AC/AC Converter

This article proposed a novel topology of dynamic voltage regulator using transformer and PWM multi-level AC/AC converter. In this paper for finding the best value of duty ratio for switches to minimize the THD, the GA algorithm has been used and THD output voltage is assumed to be fitness function. The proposed voltage regulator employs multi-level AC/AC converter to generate compensation volt...

Neuropharmacological properties of farnesol in Murine model

Research on new compounds of therapeutic value for behavioral disorders has progressed recently. Several studies have reported neuropharmacological activities of plant derived terpenes. Farnesol is a sesquiterpene whose most popular source is fruits but the anxiolytic activity for farnesol is still unknown. The present study was conducted on 32 male Swiss Albino mice (8 in each group) to evalua...

Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.

5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) is a novel cognitive enhancer with central benzodiazepine receptor partial inverse agonistic activity. AC-3933 is predominantly metabolized to hydroxylated metabolite [SX-5745; 3-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)-5-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1,6-naphthyridine] in dog. Initially, we ...

Neuropharmacological Aspects of Cognitive Neurorehabilitation in Epilepsy

The role of CNS neuromodulators in cognitive neurorehabilitation can be related to two main issues: 1) the negative impact on cognition of drug categories prescribed for different neurologic symptoms, such as spasticity, extrapyramidal symptoms, or epileptic seizures; 2) their possible role in neuroprotection and amelioration of the cognitive status of the patient, especially attention and memo...

EidisineTM as a Cognitive Enhancer